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KMID : 0616120090400040388
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 4 p.388 ~ p.393
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Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (4)
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Kim Jong-Min
Kim Young-Sook
Kim Joo-Hwan
Yoo Jeong-Lim
Kim Jin-Sook
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Abstract
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Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The
AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines (IC50<50 μg/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, IC50=75.98 μg/ml; 28 days, IC50=88.27 μg/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.
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KEYWORD
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Advanced glycation end products, AGEs, diabetic complications, herbal medicines
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